What are some biological factors that can underly intersex? Note: A number of the items that will be linked to below are in the process of being edited for inaccuracies. They include… 17-beta-hydroxysteroid dehydrogenase deficiency 5-alpha reductase deficiency Androgen Insensitivity Syndrome – AIS Ambiguous genitalia Aphallia Clitoromegaly Congenital Adrenal Hyperplasia – CAH Cryptorchidism Endocrine-disrupting chemicals…

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5-ALPHA reductase deficiency, commonly shortened to “5-alpha” by community members and allies, is similar to the androgen resistance syndromes – AIS. Individuals with 5-alpha have XY chromosomes and testes but appear phenotypically female at birth. This variation results from the body’s failure to convert testosterone to dihydrotestosterone, the more powerful form of androgen responsible for the…

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